Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Stable Identifier
R-HSA-159854
DOI
10.3180/REACT_1132.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
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A number of proteins, including eight required for normal blood clot formation and its regulation (Prothrombin (factor II), factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas6) share a sequence motif rich in glutamate residues near their amino termini. Carboxylation of the glutamate residues within this motif followed by removal of an aminoterminal propeptide is required for each of these proteins to function. These modifications occur as the proteins move through the endoplasmic reticulum and Golgi apparatus.
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Events
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as an event of
Event Information
Go Biological Process
peptidyl-glutamic acid carboxylation (0017187)
Orthologous Events
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Bos taurus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Canis familiaris)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Danio rerio)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Gallus gallus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Mus musculus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Rattus norvegicus)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Sus scrofa)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Xenopus tropicalis)
Authored
D'Eustachio, P  (2005-03-17)
Reviewed
Stafford, DW  (2025-03-04)
Created
D'Eustachio, P  (2005-03-17)
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