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Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
Stable Identifier
R-HSA-163841
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
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After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the vitamin K-dependent attachment of carboxyl groups to glutamate residues and the conversion of a lysine residue in eIF5A to hypusine, the conversion of a histidine residue in EEF to diphthamide, and the hydrxylation of various amino acid side chains.
Participants
Events
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
(Homo sapiens)
Hypusine synthesis from eIF5A-lysine
(Homo sapiens)
Synthesis of diphthamide-EEF2
(Homo sapiens)
The activation of arylsulfatases
(Homo sapiens)
ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins
(Homo sapiens)
FN3K phosphorylates ketosamines
(Homo sapiens)
FN3KRP phosphorylates PsiAm, RibAm
(Homo sapiens)
TPST1,2 transfer SO4(2-) from PAPS to FVIII
(Homo sapiens)
Protein hydroxylation
(Homo sapiens)
Participates
as an event of
Post-translational protein modification (Homo sapiens)
Event Information
Go Biological Process
post-translational protein modification (0043687)
Orthologous Events
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Bos taurus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Caenorhabditis elegans)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Danio rerio)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Dictyostelium discoideum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Drosophila melanogaster)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Gallus gallus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Mus musculus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Plasmodium falciparum)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Rattus norvegicus)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Saccharomyces cerevisiae)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Schizosaccharomyces pombe)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Sus scrofa)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Xenopus tropicalis)
Authored
D'Eustachio, P (2005-05-08)
Reviewed
Stafford, DW (2024-11-15)
Orlean, P (2024-11-15)
Created
D'Eustachio, P (2005-05-08)
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