crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)

Stable Identifier
R-HSA-158747
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)
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Once plasmin has been activated, in the initial stage of the fibrinolysis process, it can catalyze the conversion of fibrin-bound tissue plasminogen activator (one-chain) to its more active two-chain form, increasing the rate at which additional plasminogen molecules can be activated.
Literature References
PubMed ID Title Journal Year
2962641 Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin

Higgins, DL, Vehar, GA

Biochemistry 1987
2496749 The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site

Boose, JA, Kuismanen, E, Gerard, R, Sambrook, J, Gething, MJ

Biochemistry 1989
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Plasmin [extracellular region]

Physical Entity
Plasmin [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Bos taurus)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Canis familiaris)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Danio rerio)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Gallus gallus)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Sus scrofa)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Xenopus tropicalis)
Authored
D'Eustachio, P  (2005-02-09)
Created
D'Eustachio, P  (2005-02-09)
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