Reactome | crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)

crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)

Stable Identifier

R-HSA-158747

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)

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Once plasmin has been activated, in the initial stage of the fibrinolysis process, it can catalyze the conversion of fibrin-bound tissue plasminogen activator (one-chain) to its more active two-chain form, increasing the rate at which additional plasminogen molecules can be activated.

Literature References

PubMed ID	Title	Journal	Year
2962641	Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin Higgins, DL, Vehar, GA	Biochemistry	1987
2496749	The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site Boose, JA, Sambrook, J, Gething, MJ, Gerard, R, Kuismanen, E	Biochemistry	1989