Once plasmin has been activated, in the initial stage of the fibrinolysis process, it can catalyze the conversion of fibrin-bound tissue plasminogen activator (one-chain) to its more active two-chain form, increasing the rate at which additional plasminogen molecules can be activated.
Higgins, DL, Vehar, GA
Boose, JA, Sambrook, J, Gething, MJ, Gerard, R, Kuismanen, E
serine-type endopeptidase activity of Plasmin [extracellular region]
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