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Plasmin
Stable Identifier
R-HSA-158770
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP10 (Homo sapiens)
proMMP10 activators [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Activation of proMMP8 (Homo sapiens)
proMMP8 initial activators [extracellular region] (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Initial activation of proMMP1 (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Initial activation of proMMP3 (Homo sapiens)
proMMP3 initial activators [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Initial activation of proMMP7 by trypsin (Homo sapiens)
MMP7 initial activators [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
E-cadherin degradation by MMP3, MMP7 and plasmin. (Homo sapiens)
MMP3, MMP7, Plasmin [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)
MMP3, plasmin, (MMP12) [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)
Laminin-332 degrading extracellular proteinases [extracellular region] (Homo sapiens)
Plasmin, BMP1 [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
alpha-2-antiplasmin:plasmin [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Extracellular processing of novel PDGFs (Homo sapiens)
serine-type endopeptidases involved in novel PDGF processing [extracellular region] (Homo sapiens)
Plasmin [extracellular region] (Homo sapiens)
Participants
components
PLG(20-580) [extracellular region] (Homo sapiens)
PLG(581-810) [extracellular region] (Homo sapiens)
Participant Of
hasCandidate
MMP7 initial activators [extracellular region]
hasMember
MMP3, MMP7, Plasmin [extracellular region]
MMP3, plasmin, (MMP12) [extracellular region]
Plasmin, BMP1 [extracellular region]
proMMP1 initial activators [extracellular region]
proMMP10 activators [extracellular region]
proMMP3 initial activators [extracellular region]
serine-type endopeptidases involved in novel PDGF processing [extracellular region]
Trypsin, plasmin [extracellular region]
input
alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin
output
crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
hasComponent
alpha-2-antiplasmin:plasmin [extracellular region]
Inferred To
Plasmin [extracellular region] (Bos taurus)
Plasmin [extracellular region] (Caenorhabditis elegans)
Plasmin [extracellular region] (Canis familiaris)
Plasmin [extracellular region] (Danio rerio)
Plasmin [extracellular region] (Drosophila melanogaster)
Plasmin [extracellular region] (Gallus gallus)
Plasmin [extracellular region] (Mus musculus)
Plasmin [extracellular region] (Rattus norvegicus)
Plasmin [extracellular region] (Sus scrofa)
Plasmin [extracellular region] (Taeniopygia guttata)
Plasmin [extracellular region] (Xenopus tropicalis)
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