Reactome | histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen

histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen

Stable Identifier

R-HSA-158722

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

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histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen

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Plasminogen reversibly binds histidine-rich glycoprotein (HRG). The resulting complex interacts poorly with fibrin, suggesting that HRG might have an anti-fibrinolytic (clot-stabilizing) effect in vivo (Lijnen et al. 1980). Consistent with this suggestion, individuals with chronically reduced plasma HRG concentrations are susceptible to thrombosis (Shigekiyo et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
3011081	Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA Yoshitake, S, Koide, T, Foster, D, Davie, EW	Biochemistry	1986
6448849	Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. Role in the regulation of fibrinolysis and identification as histidine-rich glycoprotein. Hoylaerts, M, Lijnen, HR	J Biol Chem	1980
9414276	HRG Tokushima: molecular and cellular characterization of histidine-rich glycoprotein (HRG) deficiency Fujikawa, K, Yoshida, H, Koide, T, Matsumoto, K, Shigekiyo, T, Azuma, H, Wakabayashi, S, Saito, S	Blood	1998