Plasminogen reversibly binds histidine-rich glycoprotein (HRG). The resulting complex interacts poorly with fibrin, suggesting that HRG might have an anti-fibrinolytic (clot-stabilizing) effect in vivo (Lijnen et al. 1980). Consistent with this suggestion, individuals with chronically reduced plasma HRG concentrations are susceptible to thrombosis (Shigekiyo et al. 1998).
Yoshitake, S, Koide, T, Foster, D, Davie, EW
Hoylaerts, M, Lijnen, HR
Fujikawa, K, Yoshida, H, Koide, T, Matsumoto, K, Shigekiyo, T, Azuma, H, Wakabayashi, S, Saito, S
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