Reactome | CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO

CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO

Stable Identifier

R-HSA-156526

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Aflatoxin B1 oxidized to Aflatoxin-8,9-oxide

ReviewStatus

5/5

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CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO

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Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFXBO). This conversion is carried out by at least four P450s; 1A2, 3A4, 3A5 and 2A13. CYP3A4 mainly produces the exo form whereas CYP1A2 produces a racemic mixture of exo and endo forms (Gallagher et al. 1996, He et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
8975785	The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 Gallagher, EP, Kunze, KL, Stapleton, PL, Eaton, DL	Toxicol. Appl. Pharmacol.	1996
16385575	Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract He, XY, Tang, L, Wang, SL, Cai, QS, Wang, JS, Hong, JY	Int. J. Cancer	2006