PC is converted to PS by PTDSS1

Stable Identifier
R-HSA-1483186
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidylserine synthase 1 (PTDSS1) converts phosphatidylcholine (PC) into phosphatidylserine (PS) by facilitating the exchange of L-Serine (L-Ser) with the choline (Cho) head group (Saito et al. 1998, Tomohiro et al. 2009).

Literature References
PubMed ID Title Journal Year
19014349 Purification and characterization of human phosphatidylserine synthases 1 and 2

Tomohiro, S, Kawaguti, A, Kawabe, Y, Kitada, S, Kuge, O

Biochem J 2009
9642289 Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells

Saito, K, Nishijima, M, Kuge, O

J Biol Chem 1998
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transferase activity of PTDSS1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created