Reactome | PG and CDP-DAG are converted to CL by CRLS1

PG and CDP-DAG are converted to CL by CRLS1

Stable Identifier

R-HSA-1483063

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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PG and CDP-DAG are converted to CL by CRLS1

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At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) converts phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) into cardiolipin (CL) (Lu et al. 2006, Houtkooper et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16678169	Identification and characterization of human cardiolipin synthase Houtkooper, RH, Akbari, H, van Lenthe, H, Kulik, W, Wanders, RJA, Frentzen, M, Vaz, FM	FEBS Lett	2006
16547353	Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1) Lu, B, Xu, FY, Jiang, YJ, Choy, PC, Hatch, GM, Grunfeld, C, Feingold, KR	J Lipid Res	2006