PG and CDP-DAG are converted to CL by CRLS1

Stable Identifier
R-HSA-1483063
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) converts phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) into cardiolipin (CL) (Lu et al. 2006, Houtkooper et al. 2006).

Literature References
PubMed ID Title Journal Year
16678169 Identification and characterization of human cardiolipin synthase

van Lenthe, H, Vaz, FM, Houtkooper, RH, Kulik, W, Akbari, H, Wanders, RJ, Frentzen, M

FEBS Lett 2006
16547353 Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)

Hatch, GM, Feingold, KR, Lu, B, Grunfeld, C, Xu, FY, Jiang, YJ, Choy, PC

J Lipid Res 2006
Participants
Participates
Catalyst Activity

CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity of CRLS1 [mitochondrial inner membrane]

Orthologous Events
Authored
Created
Cite Us!