Reactome | PG and CDP-DAG are converted to CL by CRLS1

PG and CDP-DAG are converted to CL by CRLS1

Stable Identifier

R-HSA-1483063

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

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PG and CDP-DAG are converted to CL by CRLS1

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At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) converts phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) into cardiolipin (CL) (Lu et al. 2006, Houtkooper et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16547353	Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1) Lu, B, Xu, FY, Jiang, YJ, Choy, PC, Hatch, GM, Grunfeld, C, Feingold, KR	J Lipid Res	2006
16678169	Identification and characterization of human cardiolipin synthase Houtkooper, RH, Akbari, H, van Lenthe, H, Kulik, W, Wanders, RJ, Frentzen, M, Vaz, FM	FEBS Lett	2006