PG and CDP-DAG are converted to CL by CRLS1

Stable Identifier
R-HSA-1483063
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) converts phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) into cardiolipin (CL) (Lu et al. 2006, Houtkooper et al. 2006).

Literature References
PubMed ID Title Journal Year
16547353 Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)

Lu, B, Xu, FY, Jiang, YJ, Choy, PC, Hatch, GM, Grunfeld, C, Feingold, KR

J Lipid Res 2006
16678169 Identification and characterization of human cardiolipin synthase

Houtkooper, RH, Akbari, H, van Lenthe, H, Kulik, W, Wanders, RJ, Frentzen, M, Vaz, FM

FEBS Lett 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity of CRLS1 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created