Synthesis of CL

Stable Identifier
R-HSA-1483076
Type
Pathway
Species
Homo sapiens
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Cardiolipin(CL) is synthesized in the inner mitochondrial membrane, when phosphatidylglycerol (PG) and cytidine diphosphate-diacylglycerol (CDP-DAG) are converted into CL. In addition to be synthesized in mitochondria, CDP-DAG may also be imported from ER to serve as the cardiolipin precursor pool. PGP (phosphatidylglycerol phosphate) catalyzes rate limiting step of cardiolipin biosynthesis.

Literature References
PubMed ID Title Journal Year
16547353 Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)

Lu, B, Xu, FY, Jiang, YJ, Choy, PC, Hatch, GM, Grunfeld, C, Feingold, KR

J Lipid Res 2006
16678169 Identification and characterization of human cardiolipin synthase

Houtkooper, RH, Akbari, H, van Lenthe, H, Kulik, W, Wanders, RJ, Frentzen, M, Vaz, FM

FEBS Lett 2006
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