At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 4C, PLA2G4C (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009), to form 2-acyl lysophosphatidylcholine (LPC). Cytosolic phospholipase A2 enzymes show not only PLA2 hydrolysing activity to form the 1-acyl lysophospholipid but also have a degree of PLA1 activity, producing a 2-acyl lysophospholipid.
Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K
Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH
Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T
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