Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PLA2G4C [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1498799
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytosolic phospholipase A2 gamma, cPLA2-gamma, Phospholipase A2 group IVC
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
Glycerophospholipid biosynthesis (Homo sapiens)
Acyl chain remodelling of PC (Homo sapiens)
PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Homo sapiens)
PLA2(6) [endoplasmic reticulum membrane] (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
Acyl chain remodelling of PE (Homo sapiens)
PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
Acyl chain remodelling of PI (Homo sapiens)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)
PLA2(12) [endoplasmic reticulum membrane] (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
Hydrolysis of LPC (Homo sapiens)
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
Hydrolysis of LPE (Homo sapiens)
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)
PLA2G4C [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UP65 PLA2G4C
Gene Names
PLA2G4C
Chain
chain:1-538, propeptide:539-541
Reference Genes
BioGPS Gene:8605 PLA2G4C
COSMIC (genes):PLA2G4C PLA2G4C
CTD Gene:8605 PLA2G4C
dbSNP Gene:8605 PLA2G4C
ENSEMBL:ENSG00000105499 PLA2G4C
HGNC:9037 PLA2G4C
KEGG:hsa:8605 PLA2G4C
Monarch:8605 PLA2G4C
NCBI Gene:8605 PLA2G4C
OMIM:603602 PLA2G4C
UCSC:Q9UP65 PLA2G4C
Reference Transcript
RefSeq:NM_003706.2 PLA2G4C
RefSeq:NM_001159323.1 PLA2G4C
RefSeq:NM_001159322.1 PLA2G4C
Other Identifiers
11721564_a_at
11762824_at
11762825_x_at
1554810_PM_at
1554810_at
16873826
16873846
17117831
209785_PM_s_at
209785_s_at
33707_at
3866846
3866847
3866848
3866849
3866850
3866852
3866854
3866855
3866856
3866857
3866858
3866859
3866860
3866861
3866862
3866863
3866864
3866865
3866866
3866867
3866868
3866873
3866874
3866875
3866876
3866877
3866880
3866881
3866882
3866883
3866884
3866885
3866886
3866887
3866888
3866889
3866890
3866891
3866892
3866893
3866894
3866895
8037970
8605
ADDON000490.hg
ADDON002060.hg
A_21_P0014368
A_23_P50508
A_24_P316439
GE54546
GO:0003824
GO:0004620
GO:0004622
GO:0004623
GO:0005509
GO:0005515
GO:0005543
GO:0005544
GO:0005635
GO:0005654
GO:0005739
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006629
GO:0006644
GO:0006650
GO:0006663
GO:0006954
GO:0007567
GO:0008289
GO:0008374
GO:0008970
GO:0009395
GO:0016020
GO:0016042
GO:0016740
GO:0016787
GO:0019369
GO:0022414
GO:0031966
GO:0035556
GO:0036151
GO:0036152
GO:0043226
GO:0046475
GO:0046486
GO:0047498
GO:0047499
GO:0140042
HMNXSV003008363
HMNXSV003039045
HMNXSV003042346
HMNXSV003046728
Hs2.18858.2.S1_3p_at
ILMN_1810191
PH_hs_0001664
TC19001674.hg
TC19001675.hg
g3811344_3p_a_at
p25102
Participates
as a member of
PLA2(6) [endoplasmic reticulum membrane] (Homo sapiens)
PLA2(12) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
PLB2 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
PLB1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
PLB3 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
Homologues of PLA2G4C [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
Homologues of PLA2G4C [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
SPO1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
Pla2g4c [endoplasmic reticulum membrane]
(Mus musculus)
Pla2g4c [endoplasmic reticulum membrane]
(Rattus norvegicus)
PLA2G4C [endoplasmic reticulum membrane]
(Danio rerio)
PLA2G4C [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
plb1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001152795.1
,
NP_003697.2
,
NP_001152794.1
Guide to Pharmacology - Targets
1426
ENSEMBL
ENSP00000469473
,
ENSP00000346228
,
ENST00000354276
,
ENSP00000472546
,
ENST00000599111
,
ENST00000599921
OpenTargets
ENSG00000105499
IntEnz
3.1.1.5
HPA
ENSG00000105499-PLA2G4C
ZINC - Substances
PA24C_HUMAN
ZINC target
Q9UP65
PRO
Q9UP65
Pharos - Targets
Q9UP65
ZINC - Predictions - Purchasable
PA24C_HUMAN
HMDB Protein
HMDBP00529
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-25847655 CCSB
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text