CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)

Stable Identifier
R-HSA-1482794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) to monolysocardiolipin (MLCL) and phosphatidylcholine (PC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009).

Literature References
PubMed ID Title Journal Year
14551214 Remodeling of cardiolipin by phospholipid transacylation

Xu, Y, Kelley, RI, Blanck, TJ, Schlame, M

J Biol Chem 2003
19416660 Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Malhotra, A, Xu, Y, Ren, M, Schlame, M

Biochim Biophys Acta 2009
17082194 The enzymatic function of tafazzin

Xu, Y, Malhotra, A, Ren, M, Schlame, M

J Biol Chem 2006
Participants
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Event Information
Catalyst Activity
Catalyst Activity
Title
1-acylglycerophosphocholine O-acyltransferase activity of TAZ [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created