Reactome | CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)

CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)

Stable Identifier

R-HSA-1482794

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)

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At the inner mitochondrial membrane (IM), tafazzin (TAZ) converts cardiolipin (CL) and 1-acyl lysophosphatidylcholine (LPC) to monolysocardiolipin (MLCL) and phosphatidylcholine (PC) (Xu et al. 2003, Xu et al. 2006, Malhotra et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19416660	Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Ren, M, Schlame, M, Xu, Y, Malhotra, A	Biochim Biophys Acta	2009
14551214	Remodeling of cardiolipin by phospholipid transacylation Schlame, M, Xu, Y, Blanck, TJ, Kelley, RI	J Biol Chem	2003
17082194	The enzymatic function of tafazzin Ren, M, Schlame, M, Xu, Y, Malhotra, A	J Biol Chem	2006