PS is hydrolyzed to 1-acyl LPS by PLA2G2A

Stable Identifier
R-HSA-1482776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PS is hydrolyzed to 1-acyl LPS by PLA2G2A
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At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A, PLA2G2A, to form 1-acyl lysophosphatidylserine (LPS) (Singer et al. 2002).
Literature References
PubMed ID Title Journal Year
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E

J Biol Chem 2002
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Catalyst Activity

phospholipase A2 activity of PLA2G2A:Ca2+ [endoplasmic reticulum membrane]

Physical Entity
PLA2G2A:Ca2+ [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phospholipase A2 activity (GO:0004623)
Orthologous Events
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Caenorhabditis elegans)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Drosophila melanogaster)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Gallus gallus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)
PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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