Reactome | Acyl chain remodelling of PS

Acyl chain remodelling of PS

Stable Identifier

R-HSA-1482801

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

In the acyl chain remodelling pathway (Lands cycle), phosphatidylserine (PS) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008; Hishikawa et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH	J Biol Chem	2010
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE	J Biol Chem	2008
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH	J Biol Chem	2002
18287005	Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T	Proc Natl Acad Sci U S A	2008