PS is hydrolyzed to 1-acyl LPS by PLA2[9]

Stable Identifier
R-HSA-1482771
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the endoplasmic reticulum (ER) membrane, phosphatidylserine (PS) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A,B,D/E/F) (Ghomashchi et al. 2010), or by group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008). This produces 1-acyl lysophosphatidylserine (LPS).

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC

J Biol Chem 2010
18614531 Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

Duncan, RE, Ahmadian, M, Jaworski, K, Sarkadi-Nagy, E, Sul, HS

J Biol Chem 2008
Participants
Participates
Catalyst Activity

phospholipase A2 activity of PLA2(9) [cytosol]

Orthologous Events
Authored
Created
Cite Us!