Reactome | PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)

PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)

Stable Identifier

R-HSA-1482745

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane (IM), phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 beta (PLA2G4B) to form 1-acyl lysophosphatidylglycerol (LPG) (Ghomashchi et al. 2010, Singer et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH	J Biol Chem	2010
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH	J Biol Chem	2002