2-acyl LPS is acylated to PS by LPSAT

Stable Identifier
R-HSA-1482691
Type
Reaction
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References
PubMed ID Title Journal Year
18772128 Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils

Zarini, S, Voelker, DR, Riekhof, WR, Gijon, MA, Murphy, RC

J Biol Chem 2008
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Revett, T, Tobin, JF, Cao, J, Li, D, Shan, D, Gimeno, RE, Wu, L, Liu, W

J Biol Chem 2008
18287005 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

Shindou, H, Nakanishi, H, Taguchi, R, Kobayashi, S, Shimizu, T, Hishikawa, D

Proc Natl Acad Sci U S A 2008
Participants
Participates
Catalyst Activity

2-acylglycerol-3-phosphate O-acyltransferase activity of LPSAT [endoplasmic reticulum membrane]

Orthologous Events
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