2-acyl LPS is acylated to PS by LPSAT

Stable Identifier
R-HSA-1482691
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
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2-acyl LPS is acylated to PS by LPSAT
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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References
PubMed ID Title Journal Year
18772128 Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils

Zarini, S, Voelker, DR, Riekhof, WR, Gijon, MA, Murphy, RC

J Biol Chem 2008
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Revett, T, Tobin, JF, Cao, J, Li, D, Shan, D, Gimeno, RE, Wu, L, Liu, W

J Biol Chem 2008
18287005 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

Shindou, H, Nakanishi, H, Taguchi, R, Kobayashi, S, Shimizu, T, Hishikawa, D

Proc Natl Acad Sci U S A 2008
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Catalyst Activity

2-acylglycerol-3-phosphate O-acyltransferase activity of LPSAT [endoplasmic reticulum membrane]

Physical Entity
LPSAT [endoplasmic reticulum membrane] (Homo sapiens)
Activity
2-acylglycerol-3-phosphate O-acyltransferase activity (GO:0047144)
Orthologous Events
2-acyl LPS is acylated to PS by LPSAT (Bos taurus)
2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)
2-acyl LPS is acylated to PS by LPSAT (Canis familiaris)
2-acyl LPS is acylated to PS by LPSAT (Danio rerio)
2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)
2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)
2-acyl LPS is acylated to PS by LPSAT (Gallus gallus)
2-acyl LPS is acylated to PS by LPSAT (Mus musculus)
2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)
2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)
2-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)
2-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)
2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)
2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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