Reactome | 2-acyl LPS is acylated to PS by LPSAT

2-acyl LPS is acylated to PS by LPSAT

Stable Identifier

R-HSA-1482691

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 2-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE	J Biol Chem	2008
18772128	Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR	J Biol Chem	2008
18287005	Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T	Proc Natl Acad Sci U S A	2008