Reactome | 1-acyl LPS is acylated to PS by LPSAT

1-acyl LPS is acylated to PS by LPSAT

Stable Identifier

R-HSA-1482636

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18772128	Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR	J Biol Chem	2008
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE	J Biol Chem	2008
18287005	Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T	Proc Natl Acad Sci U S A	2008