1-acyl LPS is acylated to PS by LPSAT

Stable Identifier
R-HSA-1482636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylserine (LPS) to form phosphatidylserine (PS). The lysophospholipid acyltransferases involved are: lysophospholipid acyltransferase 5 (LPCAT3) (Gijon et al. 2008, Hishikawa et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008); or lysophospholipid acyltransferase 1 (MBOAT1) aka LPEAT1 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References
PubMed ID Title Journal Year
18458083 Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE

J Biol Chem 2008
18772128 Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils

Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR

J Biol Chem 2008
18287005 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

Hishikawa, D, Shindou, H, Kobayashi, S, Nakanishi, H, Taguchi, R, Shimizu, T

Proc Natl Acad Sci U S A 2008
Participants
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Catalyst Activity
Catalyst Activity
Title
1-acylglycerol-3-phosphate O-acyltransferase activity of LPSAT [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created