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GalNAc-MUC5AC [Golgi lumen]
Stable Identifier
R-HSA-1463440
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
Tn antigen (MUC5AC)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with O-glycosylation of proteins (Homo sapiens)
Defective C1GALT1C1 causes TNPS (Homo sapiens)
Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
Termination of O-glycan biosynthesis (Homo sapiens)
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC5AC [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98088 MUC5AC
Gene Names
MUC5AC, MUC5
Chain
signal peptide:1-27, chain:28-5654
Reference Genes
BioGPS Gene:4586 MUC5AC
COSMIC (genes):MUC5AC MUC5AC
CTD Gene:4586 MUC5AC
dbSNP Gene:4586 MUC5AC
ENSEMBL:ENSG00000215182 MUC5AC
ENSEMBL_homo_sapiens_GENE:ENSG00000215182.8 MUC5AC
ENSEMBL_homo_sapiens_GENE:ENSG00000291363.1 MUC5AC
HGNC:7515 MUC5AC
KEGG Gene (Homo sapiens):4586 MUC5AC
Monarch:4586 MUC5AC
NCBI Gene:4586 MUC5AC
OMIM:158373 MUC5AC
UCSC:P98088 MUC5AC
Reference Transcript
RefSeq:NM_001304359.1 MUC5AC
Other Identifiers
16720560
214303_PM_x_at
214303_x_at
214385_PM_s_at
214385_s_at
217187_PM_at
217187_at
298_at
41383_at
4586
A_24_P548274
A_24_P743708
A_24_P917886
A_24_P935054
A_33_P3216568
A_33_P3216570
GE60413
GE727017
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005615
GO:0005794
GO:0005796
GO:0005886
GO:0030312
GO:0031012
GO:0043226
GO:0046872
GO:0070062
GO:0070701
HMNXSV003005895
HMNXSV003019591
Hs.102482.0.A1_3p_s_at
Hs.103707.0.S1_3p_s_at
Hs.247953.0.S1_3p_at
Hs.247953.0.S1_3p_x_at
ILMN_1748303
PH_hs_0031488
PH_hs_0036201
TC11000041.hg
TC11002496.hg
TC11003511.hg
Z48314_s_at
Participates
as a member of
Tn antigens [Golgi lumen] (Homo sapiens)
Other forms of this molecule
Core 8 (MUC5AC) [Golgi lumen]
Core 2S (MUC5AC) [Golgi lumen]
Core 5 (MUC5AC) [Golgi lumen]
Core 4 (MUC5AC) [Golgi lumen]
Core 3 (MUC5AC) [Golgi lumen]
Core 7 (MUC5AC) [Golgi lumen]
extended Core 6 (MUC5AC) [Golgi lumen]
Core 6 (MUC5AC) [Golgi lumen]
GalNAc-MUC5AC [plasma membrane]
Core 2 (MUC5AC) [Golgi lumen]
Core 2a (MUC5AC) [Golgi lumen]
Sialyl Tn antigen (MUC5AC) [Golgi lumen]
T-antigen (MUC5AC) [Golgi lumen]
Sialyl-2,3 T-antigen (MUC5AC) [Golgi lumen]
Sialyl T-antigen (MUC5AC) [Golgi lumen]
Disialyl T-antigen (MUC5AC) [Golgi lumen]
MUC5AC [Golgi lumen]
Inferred To
GalNAc-MUC5AC [Golgi lumen]
(Bos taurus)
MUC5AC [Golgi lumen]
(Sus scrofa)
Muc5ac [Golgi lumen]
(Mus musculus)
Muc5ac [Golgi lumen]
(Rattus norvegicus)
Hml [Golgi lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-(N-acetylamino)galactosyl-L-serine at unknown position
PsiMod Name
O-(N-acetylamino)galactosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.
Cross References
RefSeq
NP_001291288.1
OpenTargets
ENSG00000215182
GeneCards
P98088
HPA
ENSG00000215182-MUC5AC
Ensembl
ENSG00000215182
,
ENSP00000485659
,
ENST00000621226
PRO
P98088
Pharos - Targets
P98088
PDB
5AJN
,
8OV0
,
5AJO
,
5AJP
,
8V9Q
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