Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GalNAc-MUC2 [Golgi lumen]
Stable Identifier
R-HSA-1463437
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
Tn antigen (MUC2)
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with O-glycosylation of proteins (Homo sapiens)
Defective C1GALT1C1 causes TNPS (Homo sapiens)
Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
Termination of O-glycan biosynthesis (Homo sapiens)
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)
Tn antigens [Golgi lumen] (Homo sapiens)
GalNAc-MUC2 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02817 MUC2
Gene Names
MUC2, SMUC
Chain
signal peptide:1-20, chain:21-5289
Reference Genes
BioGPS Gene:4583 MUC2
COSMIC (genes):MUC2 MUC2
CTD Gene:4583 MUC2
dbSNP Gene:4583 MUC2
HGNC:7512 MUC2
KEGG Gene (Homo sapiens):4583 MUC2
Monarch:4583 MUC2
NCBI Gene:4583 MUC2
OMIM:158370 MUC2
Reference Transcript
RefSeq:NM_002457.4 MUC2
Participates
as a member of
Tn antigens [Golgi lumen] (Homo sapiens)
Other forms of this molecule
Core 8 (MUC2) [Golgi lumen]
Core 2S (MUC2) [Golgi lumen]
Core 5 (MUC2) [Golgi lumen]
Core 4 (MUC2) [Golgi lumen]
Core 3 (MUC2) [Golgi lumen]
Core 7 (MUC2) [Golgi lumen]
extended Core 6 (MUC2) [Golgi lumen]
GalNAc-MUC2 [plasma membrane]
Core 2 (MUC2) [Golgi lumen]
Core 2a (MUC2) [Golgi lumen]
Sialyl Tn antigen (MUC2) [Golgi lumen]
T-antigen (MUC2) [Golgi lumen]
Sialyl-2,3 T-antigen (MUC2) [Golgi lumen]
Sialyl T-antigen (MUC2) [Golgi lumen]
Disialyl T-antigen (MUC2) [Golgi lumen]
MUC2 [Golgi lumen]
Core 6 (MUC2) [Golgi lumen]
Inferred To
GalNAc-MUC2 [Golgi lumen]
(Mus musculus)
GalNAc-MUC2 [Golgi lumen]
(Rattus norvegicus)
Hml [Golgi lumen]
(Drosophila melanogaster)
MUC2 [Golgi lumen]
(Bos taurus)
MUC2 [Golgi lumen]
(Canis familiaris)
MUC2 [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-(N-acetylamino)galactosyl-L-serine at unknown position
PsiMod Name
O-(N-acetylamino)galactosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.
Cross References
RefSeq
NP_002448.4
OpenTargets
ENSG00000198788
GeneCards
Q02817
PRO
Q02817
Pharos - Targets
Q02817
PDB
7QCU
,
6RBF
,
8CK2
,
8S03
,
6TM6
,
7QCN
,
7A5O
,
7POV
,
7PRL
,
6TM2
,
7PP6
,
7QCL
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text