HNP1-4 are stored in primary neutrophil granules

Stable Identifier
R-HSA-1462003
Type
Reaction [transition]
Species
Homo sapiens
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ReviewStatus
5/5
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Alpha defensins HNP1-4, the neutrophil defensins, are stored in biologically active form in neutrophil primary (azurophil) granules, where they make up 5-10% of total cellular protein in these cells (Lehrere et al. 1993). The relative amounts of peptide for HNP-1 to -3 are 2:2:1 with HNP-4 being only a minor component.
Literature References
PubMed ID Title Journal Year
2500436 Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family

Marra, MN, Griffith, JE, Wilde, CG, Snable, JL, Scott, RW

J Biol Chem 1989
2997278 Defensins. Natural peptide antibiotics of human neutrophils

Daher, K, Ganz, T, Szklarek, D, Selsted, ME, Bainton, DF, Harwig, SS, Lehrer, RI

J Clin Invest 1985
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