HNP1-4 are stored in primary neutrophil granules

Stable Identifier
R-HSA-1462003
Type
Reaction [transition]
Species
Homo sapiens
Compartment
azurophil granule lumen, Golgi lumen
ReviewStatus
5/5
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HNP1-4 are stored in primary neutrophil granules
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Alpha defensins HNP1-4, the neutrophil defensins, are stored in biologically active form in neutrophil primary (azurophil) granules, where they make up 5-10% of total cellular protein in these cells (Lehrere et al. 1993). The relative amounts of peptide for HNP-1 to -3 are 2:2:1 with HNP-4 being only a minor component.
Literature References
PubMed ID Title Journal Year
2500436 Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family

Wilde, CG, Griffith, JE, Marra, MN, Snable, JL, Scott, RW

J Biol Chem 1989
2997278 Defensins. Natural peptide antibiotics of human neutrophils

Ganz, T, Selsted, ME, Szklarek, D, Harwig, SS, Daher, K, Bainton, DF, Lehrer, RI

J Clin Invest 1985
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HNP1-4 are stored in primary neutrophil granules (Mus musculus)
HNP1-4 are stored in primary neutrophil granules (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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