HNP1-4 are stored in primary neutrophil granules

Stable Identifier
R-HSA-1462003
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Alpha defensins HNP1-4, the neutrophil defensins, are stored in biologically active form in neutrophil primary (azurophil) granules, where they make up 5-10% of total cellular protein in these cells (Lehrere et al. 1993). The relative amounts of peptide for HNP-1 to -3 are 2:2:1 with HNP-4 being only a minor component.

Literature References
PubMed ID Title Journal Year
2997278 Defensins. Natural peptide antibiotics of human neutrophils

Ganz, T, Selsted, ME, Szklarek, D, Harwig, SS, Daher, K, Bainton, DF, Lehrer, RI

J Clin Invest 1985
2500436 Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family

Wilde, CG, Griffith, JE, Marra, MN, Snable, JL, Scott, RW

J Biol Chem 1989
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created