p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)

Stable Identifier
R-HSA-1445144
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol
ReviewStatus
5/5
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p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
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As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).
Literature References
PubMed ID Title Journal Year
15919790 Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

Karlsson, HK, Zierath, JR, Kane, S, Krook, A, Lienhard, GE, Wallberg-Henriksson, H

Diabetes 2005
17369524 Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

Howlett, KF, Sakamoto, K, Garnham, A, Cameron-Smith, D, Hargreaves, M

Diabetes 2007
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-AKT1,p-AKT2 [plasma membrane]

Physical Entity
p-AKT1,p-AKT2 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Akt Phosphorylates As160 (Tbc1d4) (Mus musculus)
Authored
May, B  (2011-07-07)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-13)
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