Phosphorylation of APS

Stable Identifier
R-HSA-1433506
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Phosphorylation of APS
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APS bound to KIT is phosphorylated by tyrosine kinases in response to SCF stimulation (Wollberg et al, 2003). The C-terminal tyrosine 629 may be the target site of phosphorylation in APS (Wakioka et al, 1999).

Literature References
PubMed ID Title Journal Year
10374881 APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl

Wakioka, T, Sasaki, A, Mitsui, K, Yokouchi, M, Inoue, A, Komiya, S, Yoshimura, A

Leukemia 1999
12444928 The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit

Wollberg, P, Lennartsson, J, Gottfridsson, E, Yoshimura, A, Rönnstrand, L

Biochem J 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of APS dimer:p-c-Kit:SFKs complex [plasma membrane]
Physical Entity
APS dimer:p-c-Kit:SFKs complex [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of APS (Bos taurus)
Phosphorylation of APS (Canis familiaris)
Phosphorylation of APS (Danio rerio)
Phosphorylation of APS (Gallus gallus)
Phosphorylation of APS (Mus musculus)
Phosphorylation of APS (Rattus norvegicus)
Phosphorylation of APS (Sus scrofa)
Phosphorylation of APS (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-07-11)