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Regulation of KIT signaling
Stable Identifier
R-HSA-1433559
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
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SCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.
Literature References
PubMed ID
Title
Journal
Year
16483568
Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
Frossard, N
,
Da Silva, CA
,
Reber, L
Eur J Pharmacol
2006
10582339
Early signaling pathways activated by c-Kit in hematopoietic cells
Linnekin, D
Int J Biochem Cell Biol
1999
Participants
Events
PKC alpha interacts with and phosphorylates KIT
(Homo sapiens)
Interaction of SHP1 and KIT
(Homo sapiens)
SOCS1 as a regulator of KIT signaling
(Homo sapiens)
Interaction of APS and p-KIT
(Homo sapiens)
Phosphorylation of APS
(Homo sapiens)
Recruitment of CBL to KIT
(Homo sapiens)
Downregulation of c-Kit signaling by SOCS6
(Homo sapiens)
LNK binds to p-KIT and inhibit downstream signaling
(Homo sapiens)
Participates
as an event of
Signaling by SCF-KIT (Homo sapiens)
Orthologous Events
Regulation of KIT signaling (Bos taurus)
Regulation of KIT signaling (Caenorhabditis elegans)
Regulation of KIT signaling (Canis familiaris)
Regulation of KIT signaling (Danio rerio)
Regulation of KIT signaling (Drosophila melanogaster)
Regulation of KIT signaling (Gallus gallus)
Regulation of KIT signaling (Mus musculus)
Regulation of KIT signaling (Rattus norvegicus)
Regulation of KIT signaling (Sus scrofa)
Regulation of KIT signaling (Xenopus tropicalis)
Authored
Garapati, P V (2011-07-11)
Reviewed
Rönnstrand, L (2011-08-22)
Created
Garapati, P V (2011-07-11)
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