Activation of RAC1

Stable Identifier
R-HSA-1433415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Vav1, once activated by PIP3 binding and phosphorylation by Src kinases, stimulates the GDP/GTP exchange activity of Rac. Vav1 is selective for Rac and catalyses exchange of bound GDP for GTP.

Literature References
PubMed ID Title Journal Year
8990121 Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Crespo, P, Schuebel, KE, Ostrom, AA, Gutkind, JS, Bustelo, XR

Nature 1997
9799234 Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

Timokhina, I, Kissel, H, Stella, G, Besmer, P

EMBO J 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-VAV1:PIP3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created