Dimerization of sSCF

Stable Identifier
R-HSA-1433395
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

sSCF exists as noncovalently associated homodimer composed of two monomers interacting head-to-head to form an elongated, slightly bent dimer. Dimerization of sSCF is a dynamic process and it may play a regulatory role in the dimerization and activation of KIT (Zhang et al, 2000; Philo et al, 1996).

Literature References
PubMed ID Title Journal Year
8636116 Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit

Wypych, J, Schwartz, MG, Langley, KE, Wen, J, Mendiaz, EA, Philo, JS

J Biol Chem 1996
10884405 Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation

Schlessinger, J, Zhang, Z, Joachimiak, A, Kong, XP, Zhang, R

Proc Natl Acad Sci U S A 2000
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!