Reactome | Dimerization of sSCF

Dimerization of sSCF

Stable Identifier

R-HSA-1433395

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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sSCF exists as noncovalently associated homodimer composed of two monomers interacting head-to-head to form an elongated, slightly bent dimer. Dimerization of sSCF is a dynamic process and it may play a regulatory role in the dimerization and activation of KIT (Zhang et al, 2000; Philo et al, 1996).

Literature References

PubMed ID	Title	Journal	Year
8636116	Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit Philo, JS, Wen, J, Wypych, J, Schwartz, MG, Mendiaz, EA, Langley, KE	J Biol Chem	1996
10884405	Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation Zhang, Z, Zhang, R, Joachimiak, A, Schlessinger, J, Kong, XP	Proc Natl Acad Sci U S A	2000