Reactome | KITLG-1(26-190) [extracellular region]

KITLG-1(26-190) [extracellular region]

Stable Identifier

R-HSA-708330

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

sSCF, soluble SCF

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
        
        sSCF dimer [extracellular region] (Homo sapiens)
        
        KITLG-1(26-190) [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
        
        sSCF dimer [extracellular region] (Homo sapiens)
        
        KITLG-1(26-190) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21583-1 KITLG

Gene Names

KITLG, MGF, SCF

Other Identifiers

0000360164

0004670632

11728954_a_at

11728955_a_at

11737779_a_at

16768270

207029_PM_at

207029_at

211124_PM_s_at

211124_s_at

226534_PM_at

226534_at

3464751

3464752

3464753

3464758

3464759

3464762

3464763

3464764

3464765

3464766

3464767

3464768

3464771

3464774

3464777

3464779

4254

597_at

62480_at

7965322

83799_at

A_23_P204654

A_24_P133253

GE535304

GE539466

GO:0001541

GO:0001755

GO:0002244

GO:0002376

GO:0002573

GO:0002687

GO:0002763

GO:0005125

GO:0005173

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005856

GO:0005886

GO:0006915

GO:0007155

GO:0007165

GO:0007265

GO:0008083

GO:0008283

GO:0008284

GO:0008584

GO:0012501

GO:0014070

GO:0016020

GO:0016021

GO:0018108

GO:0022414

GO:0023052

GO:0030027

GO:0030154

GO:0030175

GO:0033024

GO:0033026

GO:0035162

GO:0035234

GO:0036211

GO:0042098

GO:0042102

GO:0042995

GO:0043066

GO:0043226

GO:0043406

GO:0045636

GO:0046579

GO:0048856

GO:0048870

GO:0050731

GO:0070662

GO:0070668

GO:0097192

GO:0097324

GO:0097531

GO:0098772

GO:1901534

GO:1902035

HMNXSV003048894

Hs.5921.0.A1_3p_at

ILMN_1746232

ILMN_1808508

ILMN_2341595

M59964_at

PH_hs_0000136

TC12001792.hg

g4505174_3p_at

g4530470_3p_a_at

Participates

as an input of

Dimerization of sSCF (Homo sapiens)

as an output of

Processing of SCF isoform 1 (Homo sapiens)

as a component of

sSCF dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

KITLG-1(192-273) [extracellular region]

KITLG-1 [plasma membrane]

Inferred To

KITLG [extracellular region] (Bos taurus)

KITLG [extracellular region] (Canis familiaris)

KITLG [extracellular region] (Gallus gallus)

KITLG [extracellular region] (Sus scrofa)

kitlg [extracellular region] (Xenopus tropicalis)

Kitlg [extracellular region] (Mus musculus)

Kitlg [extracellular region] (Rattus norvegicus)

kitla [extracellular region] (Danio rerio)

Ghost homologue of KITLG-1(26-190) [extracellular region] (Caenorhabditis elegans)

Ghost homologue of KITLG-1(26-190) [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_003985.2, NP_000890.1

OpenTargets

ENSG00000049130

GeneCards

P21583

HPA

ENSG00000049130-KITLG

Ensembl

ENST00000644744, ENSP00000054216, ENSP00000495951, ENST00000347404, ENSG00000049130

PRO

P21583

Pharos - Targets

P21583

Orphanet

18457

HMDB Protein

HMDBP12111

PDB

2E9W, 1EXZ, 1SCF

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.544	2

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