Reactome | KITLG-1(26-190) [extracellular region]

KITLG-1(26-190) [extracellular region]

Stable Identifier

R-HSA-708330

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

sSCF, soluble SCF

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
        
        sSCF dimer [extracellular region] (Homo sapiens)
        
        KITLG-1(26-190) [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
        
        sSCF dimer [extracellular region] (Homo sapiens)
        
        KITLG-1(26-190) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21583-1 KITLG

Gene Names

KITLG, MGF, SCF

Other Identifiers

0000360164

0004670632

11728954_a_at

11728955_a_at

11737779_a_at

16768270

207029_at

211124_s_at

226534_at

3464751

3464752

3464753

3464758

3464759

3464762

3464763

3464764

3464765

3464766

3464767

3464768

3464771

3464774

3464777

3464779

4254

597_at

62480_at

7965322

83799_at

A_23_P204654

A_24_P133253

GE535304

GE539466

GO:0000003

GO:0000165

GO:0001541

GO:0001755

GO:0002376

GO:0002687

GO:0002763

GO:0003674

GO:0005125

GO:0005173

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005856

GO:0005886

GO:0006464

GO:0007155

GO:0007165

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008584

GO:0009790

GO:0016020

GO:0016021

GO:0030027

GO:0030154

GO:0030175

GO:0033026

GO:0035162

GO:0035234

GO:0040011

GO:0042592

GO:0042995

GO:0043066

GO:0043226

GO:0043406

GO:0043473

GO:0045636

GO:0046579

GO:0048856

GO:0048870

GO:0050731

GO:0051897

GO:0070668

GO:0097192

GO:1901534

GO:1902035

Hs.5921.0.A1_3p_at

ILMN_1746232

ILMN_1808508

ILMN_2341595

M59964_at

PH_hs_0000136

TC12001792.hg

g4505174_3p_at

g4530470_3p_a_at

Participant Of

output

Processing of SCF isoform 1

input

Dimerization of sSCF

hasComponent

sSCF dimer [extracellular region]

Other forms of this molecule

KITLG-1(192-273) [extracellular region]

KITLG-1 [plasma membrane]

Inferred To

kitlga [extracellular region] (Danio rerio)

KITLG [extracellular region] (Canis familiaris)

trip4 [extracellular region] (Xenopus tropicalis)

Kitlg [extracellular region] (Mus musculus)

Kitlg [extracellular region] (Rattus norvegicus)

Ghost homologue of KITLG-1(26-190) [extracellular region] (Bos taurus)

Ghost homologue of KITLG-1(26-190) [extracellular region] (Drosophila melanogaster)

KITLG-1(26-190) [extracellular region] (Gallus gallus)

KITLG-1(26-190) [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000890.1, NP_003985.2

OpenTargets

ENSG00000049130

GeneCards

P21583

HPA

ENSG00000049130-KITLG

Ensembl

ENST00000644744, ENST00000347404, ENSP00000495951, ENSP00000054216, ENSG00000049130

PRO

P21583

Orphanet

18457

PDB

1SCF, 2E9W, 1EXZ

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10721 KIT	111	KIT T417-D419delinsY [plasma membrane] (R-HSA-9680110) KIT C443Y [plasma membrane] (R-HSA-9680045) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617) p7Y-KIT N822D [plasma membrane] (R-HSA-9669613) p7Y-KIT N822S [plasma membrane] (R-HSA-9669614) p-7Y KIT V654E [plasma membrane] (R-HSA-9669615) p7Y-KIT N822I [plasma membrane] (R-HSA-9669608) p7Y-KIT D816N [plasma membrane] (R-HSA-9669611) p7Y-KIT A829P [plasma membrane] (R-HSA-9669605) p7Y-KIT D816H [plasma membrane] (R-HSA-9669606) p6Y-KIT Y823C [plasma membrane] (R-HSA-9669607) p7Y-KIT K642Q [plasma membrane] (R-HSA-9669601) p6Y-KIT Y823N [plasma membrane] (R-HSA-9669597) p7Y-KIT D816A [plasma membrane] (R-HSA-9669629) p7Y-KIT N822H [plasma membrane] (R-HSA-9669598) p7Y-KIT D816F [plasma membrane] (R-HSA-9671513) p-7Y KIT V654A [plasma membrane] (R-HSA-9669593) p7Y-KIT N822T [plasma membrane] (R-HSA-9669622) p7Y-KIT D816E [plasma membrane] (R-HSA-9671510) p7Y-KIT D816Y [plasma membrane] (R-HSA-9669623) p7Y-KIT N822Y [plasma membrane] (R-HSA-9669619) p7Y-KIT V559D [plasma membrane] (R-HSA-9669620) p7Y-KIT K550I P551_V555del [plasma membrane] (R-HSA-9669602) p-7Y KIT W557_K558del [plasma membrane] (R-HSA-9670352) p-5Y KIT V560_L576del [plasma membrane] (R-HSA-9670348) p7Y-KIT L576P [plasma membrane] (R-HSA-9669616) p7Y-KIT V559_V560del [plasma membrane] (R-HSA-9669618) p7Y-KIT P551_V555del [plasma membrane] (R-HSA-9669621) p7Y-KIT V560G [plasma membrane] (R-HSA-9669610) p7Y-KIT K550_K558del [plasma membrane] (R-HSA-9669624) p7Y-KIT V560E [plasma membrane] (R-HSA-9669603) p7Y-KIT V560D [plasma membrane] (R-HSA-9669626) p7Y-KIT V559A [plasma membrane] (R-HSA-9669625) p7Y-KIT V559I [plasma membrane] (R-HSA-9669609) p7Y-KIT W557R [plasma membrane] (R-HSA-9669627) p7Y-KIT V559G [plasma membrane] (R-HSA-9669600) p7Y-KIT W557G [plasma membrane] (R-HSA-9669604) p7Y-KIT K509I [plasma membrane] (R-HSA-9680180) p7Y-KIT A502_Y503dup [plasma membrane] (R-HSA-9680120) p7Y-KIT S476I [plasma membrane] (R-HSA-9680156) p7Y-KIT C443Y [plasma membrane] (R-HSA-9680138) p7Y-KIT D419A [plasma membrane] (R-HSA-9680129) p7Y-KIT T417-D419delinsY [plasma membrane] (R-HSA-9680165) p7Y-KIT D419H [plasma membrane] (R-HSA-9680132) p7Y-KIT S501_A502dup [plasma membrane] (R-HSA-9680161) p7Y-KIT D419del [plasma membrane] (R-HSA-9680127) p7Y-KIT N505_F508dup [plasma membrane] (R-HSA-9680159) p7Y-KIT D419N [plasma membrane] (R-HSA-9680134) p7Y-KIT C443S [plasma membrane] (R-HSA-9680137) p7Y-KIT S476N [plasma membrane] (R-HSA-9680158) p7Y-KIT D419G [plasma membrane] (R-HSA-9680130) KIT A829P [plasma membrane] (R-HSA-9669426) KIT N822D [plasma membrane] (R-HSA-9669447) KIT V654E [plasma membrane] (R-HSA-9669576) KIT W557R [plasma membrane] (R-HSA-9669581) KIT W557G [plasma membrane] (R-HSA-9669578) KIT V559A [plasma membrane] (R-HSA-9669547) KIT K550I P551_V555del [plasma membrane] (R-HSA-9669444) KIT L576P [plasma membrane] (R-HSA-9669446) KIT V559_V560del [plasma membrane] (R-HSA-9669561) KIT P551_V555del [plasma membrane] (R-HSA-9669433) KIT V559I [plasma membrane] (R-HSA-9669557) KIT K550_K558del [plasma membrane] (R-HSA-9669461) KIT V559G [plasma membrane] (R-HSA-9669554) KIT V559D [plasma membrane] (R-HSA-9669551) KIT W557_K558del [plasma membrane] (R-HSA-9670343) KIT Y823D [plasma membrane] (R-HSA-9669587) KIT D816V [plasma membrane] (R-HSA-9669452) KIT N822Y [plasma membrane] (R-HSA-9669454) KIT T670I [plasma membrane] (R-HSA-9669545) KIT D820E [plasma membrane] (R-HSA-9669449) KIT V654A [plasma membrane] (R-HSA-9669572) KIT D816H [plasma membrane] (R-HSA-9669445) KIT K642E [plasma membrane] (R-HSA-9669443) KIT V560D [plasma membrane] (R-HSA-9669564) KIT N822H [plasma membrane] (R-HSA-9669437) KIT A502_Y503dup [plasma membrane] (R-HSA-9680030) KIT N822K [plasma membrane] (R-HSA-9669464) KIT D816Y [plasma membrane] (R-HSA-9669435) KIT D820A [plasma membrane] (R-HSA-9669460) KIT N822T [plasma membrane] (R-HSA-9669463) KIT D816F [plasma membrane] (R-HSA-9669457) KIT K642Q [plasma membrane] (R-HSA-9669468) KIT D816E [plasma membrane] (R-HSA-9669436) KIT N822I [plasma membrane] (R-HSA-9669453) KIT V560E [plasma membrane] (R-HSA-9669566) KIT N822S [plasma membrane] (R-HSA-9669466) KIT D816N [plasma membrane] (R-HSA-9669451) KIT D816A [plasma membrane] (R-HSA-9669428) KIT V560G [plasma membrane] (R-HSA-9669569) p-8Y-KIT [plasma membrane] (R-HSA-1472116) p-S741,S746-KIT [plasma membrane] (R-HSA-1433492) KIT [plasma membrane] (R-HSA-197662) p-7Y-KIT [plasma membrane] (R-HSA-205207)	0.544	2

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