Reactome | PAO:FAD oxidises NASPM to PTCN

PAO:FAD oxidises NASPM to PTCN

Stable Identifier

R-HSA-141348

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

N(1)-acetylspermidine + O2 + H2O => 3-acetamidopropanal + putrescine + H2O2

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Amine Oxidase reactions (Homo sapiens)
      - PAOs oxidise polyamines to amines (Homo sapiens)
        
        PAO:FAD oxidises NASPM to PTCN (Homo sapiens)
- Metabolism of amino acids and derivatives (Homo sapiens)
  - Metabolism of polyamines (Homo sapiens)
    - Interconversion of polyamines (Homo sapiens)
      - PAO:FAD oxidises NASPM to PTCN (Homo sapiens)

General

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Acetylated spermidine (NASPM) is oxidised by the flavoenzyme polyamine oxidase (PAOX, with FAD as cofactor) to produce putrescine (PTCN). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12477380	Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion Vujcic, S, Liang, P, Diegelman, P, Kramer, DL, Porter, CW	Biochem J	2003