Reactome | TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10

TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10

Stable Identifier

R-HSA-141316

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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General

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TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10

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Caspase-10 precursor is recruited to the TRAIL:TRAIL receptor-2:FADD complex (TNFSF10:TNFRSF10B:FADD) as well as TRAIL:TRAIL receptor-1:FADD complex (TNFSF10:TNFRSF10A:FADD) (Sprick et al. 2002) through interaction of death effector domains of caspase-10 and FADD (Wang et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11717445	Caspase-10 is an initiator caspase in death receptor signaling Wong, W, Spencer, DM, Chun, HJ, Wang, J, Lenardo, MJ	Proc Natl Acad Sci U S A	2001
12198154	Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8 Stahl, H, Weigand, MA, Grosse-Wilde, A, Sprick, MR, Rieser, E, Walczak, H	EMBO J	2002