TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10

Stable Identifier
R-HSA-141316
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10
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Caspase-10 precursor is recruited to the TRAIL:TRAIL receptor-2:FADD complex (TNFSF10:TNFRSF10B:FADD) as well as TRAIL:TRAIL receptor-1:FADD complex (TNFSF10:TNFRSF10A:FADD) (Sprick et al. 2002) through interaction of death effector domains of caspase-10 and FADD (Wang et al. 2001).
Literature References
PubMed ID Title Journal Year
11717445 Caspase-10 is an initiator caspase in death receptor signaling

Wang, J, Chun, HJ, Wong, W, Spencer, DM, Lenardo, MJ

Proc Natl Acad Sci U S A 2001
12198154 Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

Sprick, MR, Rieser, E, Stahl, H, Grosse-Wilde, A, Weigand, MA, Walczak, H

EMBO J 2002
Participants
Input
Output
Participates
as an event of
Orthologous Events
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Danio rerio)
Reviewed
Pop, C  (2013-05-22)
Salvesen, GS  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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