TNF-mediated dimerization of procaspase-8

Stable Identifier
R-HSA-141159
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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TNF-mediated dimerization of procaspase-8
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Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRADD:TRAF2:RIP1:FADD:Capase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References
PubMed ID Title Journal Year
18485876 TNF-alpha induces two distinct caspase-8 activation pathways

Wang, L, Du, F, Wang, X

Cell 2008
12620240 Insights into the regulatory mechanism for caspase-8 activation

Donepudi, M, Mac Sweeney, A, Briand, C, Grütter, MG

Mol. Cell 2003
12887920 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O, Tschopp, J

Cell 2003
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This event is regulated
Negatively by
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Reviewed
Gillespie, ME  (2012-11-19)
Pop, C  (2013-05-22)
Salvesen, GS  (2013-05-22)
Created
Tschopp, J  (2004-01-28)