Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRADD:TRAF2:RIP1:FADD:Capase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.
Grütter, MG, Briand, C, Mac Sweeney, A, Donepudi, M
Wang, X, Wang, L, Du, F
Micheau, O, Tschopp, J
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