TNF-mediated dimerization of procaspase-8

Stable Identifier
R-HSA-141159
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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TNF-mediated dimerization of procaspase-8
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Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRADD:TRAF2:RIP1:FADD:Capase-8 receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References
PubMed ID Title Journal Year
12620240 Insights into the regulatory mechanism for caspase-8 activation

Grütter, MG, Briand, C, Mac Sweeney, A, Donepudi, M

Mol. Cell 2003
18485876 TNF-alpha induces two distinct caspase-8 activation pathways

Wang, X, Wang, L, Du, F

Cell 2008
12887920 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O, Tschopp, J

Cell 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FLIP(S) [cytosol] (Homo sapiens)
Orthologous Events
TNF-mediated dimerization of procaspase-8 (Bos taurus)
TNF-mediated dimerization of procaspase-8 (Canis familiaris)
TNF-mediated dimerization of procaspase-8 (Danio rerio)
TNF-mediated dimerization of procaspase-8 (Gallus gallus)
TNF-mediated dimerization of procaspase-8 (Mus musculus)
TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
TNF-mediated dimerization of procaspase-8 (Sus scrofa)
Reviewed
Gillespie, ME  (2012-11-19)
Salvesen, GS  (2013-05-22)
Pop, C  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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