Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRAIL:TRAIL receptor-2:FADD receptor complex leading to the formation of the catalytically active form of procaspase-8.
Boatright, KM, Renatus, M, Scott, FL, Sperandio, S, Shin, H, Pedersen, IM, Ricci, JE, Edris, WA, Sutherlin, DP, Green, DR, Salvesen, GS
Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H
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