Reactome | TRAIL-mediated dimerization of procaspase-8

TRAIL-mediated dimerization of procaspase-8

Stable Identifier

R-HSA-141156

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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TRAIL-mediated dimerization of procaspase-8

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Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRAIL:TRAIL receptor-2:FADD receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References

PubMed ID	Title	Journal	Year
10894160	FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H	Immunity	2000
12620239	A unified model for apical caspase activation Boatright, KM, Renatus, M, Scott, FL, Sperandio, S, Shin, H, Pedersen, IM, Ricci, JE, Edris, WA, Sutherlin, DP, Green, DR, Salvesen, GS	Mol Cell	2003