Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRAIL:TRAIL receptor-2:FADD receptor complex leading to the formation of the catalytically active form of procaspase-8.
Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH
Sperandio, S, Shin, H, Ricci, JE, Scott, FL, Renatus, M, Sutherlin, DP, Salvesen, GS, Edris, WA, Boatright, KM, Green, DR, Pedersen, IM
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