BAD displaces tBID from BCL-2 sequestration

Stable Identifier
R-HSA-139897
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BAD displaces tBID from BCL-2 sequestration
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Short peptides representing BAD and BIX were found to bind BCL-2 displacing BID-like BH3 domains that initiate mitochondrial dysfunction.
Participants
Input
Output
Participates
as an event of
Orthologous Events
BAD displaces tBID from BCL-2 sequestration (Bos taurus)
BAD displaces tBID from BCL-2 sequestration (Canis familiaris)
BAD displaces tBID from BCL-2 sequestration (Danio rerio)
BAD displaces tBID from BCL-2 sequestration (Mus musculus)
BAD displaces tBID from BCL-2 sequestration (Sus scrofa)
BAD displaces tBID from BCL-2 sequestration (Xenopus tropicalis)
Authored
Gopinathrao, G  (2004-08-18)
Reviewed
Vaux, DL  (2024-11-15)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
Cite Us!