p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2

Stable Identifier
R-HSA-1363311
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2
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p107 (RBL1) in complex with E2F4 and DP1/2 binds to cyclin A or cyclin E in complex with CDK2 through its conserved LFG pocket domain motif and amino terminus, leading to inhibition of CDK2 kinase activity and suppression of cellular growth.

Literature References
PubMed ID Title Journal Year
9199292 p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

Dynlacht, BD, Sánchez, I, Woo, MS

Mol Cell Biol 1997
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Orthologous Events
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-14)
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