p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2

Stable Identifier
R-HSA-1363311
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p107 (RBL1) in complex with E2F4 and DP1/2 binds to cyclin A or cyclin E in complex with CDK2 through its conserved LFG pocket domain motif and amino terminus, leading to inhibition of CDK2 kinase activity and suppression of cellular growth.

Literature References
PubMed ID Title Journal Year
9199292 p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

Woo, MS, Sánchez, I, Dynlacht, BD

Mol Cell Biol 1997
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Danio rerio)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-06-14)
Cite Us!