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NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
Stable Identifier
R-HSA-1358734
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
Participants
components
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane]
(Homo sapiens)
RNF41 [cytosol]
(Homo sapiens)
Participates
as an output of
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
as an input of
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
Inferred To
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Bos taurus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Canis familiaris)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Danio rerio)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Gallus gallus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Mus musculus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Rattus norvegicus)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
(Sus scrofa)
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