RNF41 ubiquitinates activated ERBB3

Stable Identifier
R-HSA-1358792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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RNF41 ubiquitinates activated ERBB3, thereby downregulating ERBB3-mediated signaling. This reaction is part of a negative feedback loop in ERBB2:ERBB3 signaling.
Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Carraway KL, 3rd, Cao, Z, Sweeney, C, Wu, X, Yen, L

Mol Cell Biol 2007
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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