RNF41 ubiquitinates activated ERBB3

Stable Identifier
R-HSA-1358792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RNF41 ubiquitinates activated ERBB3, thereby downregulating ERBB3-mediated signaling. This reaction is part of a negative feedback loop in ERBB2:ERBB3 signaling.

Literature References
PubMed ID Title Journal Year
17210635 Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

Cao, Z, Wu, X, Yen, L, Sweeney, C, Carraway KL, 3rd

Mol Cell Biol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created