TWIK related potassium channel (TREK)

Stable Identifier
R-HSA-1299503
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TWIK related potassium channel (TREK)
Click the image above or here to open this pathway in the Pathway Browser
TREK1 and TREK 2 are activated by physiochemical changes like stretch, convex deformation of the plasma membrane, depolarization, heat and intracellular acidosis. Polyunsaturated fatty acids (PUFA) including arachidonic acid open TREK channels.
Literature References
PubMed ID Title Journal Year
19840997 AMP-activated protein kinase inhibits TREK channels

Kréneisz, O, Bayliss, DA, Benoit, JP, Mulkey, DK

J Physiol 2009
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
TWIK related potassium channel (TREK) (Bos taurus)
TWIK related potassium channel (TREK) (Caenorhabditis elegans)
TWIK related potassium channel (TREK) (Canis familiaris)
TWIK related potassium channel (TREK) (Danio rerio)
TWIK related potassium channel (TREK) (Drosophila melanogaster)
TWIK related potassium channel (TREK) (Gallus gallus)
TWIK related potassium channel (TREK) (Mus musculus)
TWIK related potassium channel (TREK) (Rattus norvegicus)
TWIK related potassium channel (TREK) (Saccharomyces cerevisiae)
TWIK related potassium channel (TREK) (Sus scrofa)
TWIK related potassium channel (TREK) (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-23)
Cite Us!