Reactome | SAM50 complex inserts proteins into mitochondrial outer membrane

SAM50 complex inserts proteins into mitochondrial outer membrane

Stable Identifier

R-HSA-1268025

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space, mitochondrial outer membrane

ReviewStatus

5/5

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SAM50 complex inserts proteins into mitochondrial outer membrane

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As inferred from the yeast SAM50 complex, the human SAMM50 Complex (SAM50 complex, TOB55 complex) inserts mainly beta-barrel proteins into the outer membrane after they have passed from the cytosol, through the TOMM40:TOMM70 complex, and into the intermembrane space.
In yeast, experimentally verified substrates of the SAM50 complex include TOM40 (TOMM40 in human), MDM10, Porin1 (VDAC1 in human), and TOM22 (TOMM22 in human). In humans, TOMM40 (Humphries et al. 2005) and VDAC1 (Kozjak-Pavlovic et al. 2007, homologous to yeast Porin1) have been shown to be substrates. Many other mitochondrial proteins are anticipated to be substrates of the SAMM50 complex.

Literature References

PubMed ID	Title	Journal	Year
17510655	Conserved roles of Sam50 and metaxins in VDAC biogenesis Kozjak-Pavlovic, V, Ross, K, Benlasfer, N, Kimmig, S, Karlas, A, Rudel, T	EMBO Rep	2007
15644312	Dissection of the mitochondrial import and assembly pathway for human Tom40 Humphries, AD, Streimann, IC, Stojanovski, D, Johnston, AJ, Yano, M, Hoogenraad, NJ, Ryan, MT	J Biol Chem	2005
19453276	Multiple pathways for mitochondrial protein traffic Endo, T, Yamano, K	Biol Chem	2009
18174896	Multiple pathways for sorting mitochondrial precursor proteins Bolender, N, Sickmann, A, Wagner, R, Meisinger, C, Pfanner, N	EMBO Rep	2008