SAM50 complex inserts proteins into mitochondrial outer membrane

Stable Identifier
R-HSA-1268025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from the yeast SAM50 complex, the human SAMM50 Complex (SAM50 complex, TOB55 complex) inserts mainly beta-barrel proteins into the outer membrane after they have passed from the cytosol, through the TOMM40:TOMM70 complex, and into the intermembrane space.
In yeast, experimentally verified substrates of the SAM50 complex include TOM40 (TOMM40 in human), MDM10, Porin1 (VDAC1 in human), and TOM22 (TOMM22 in human). In humans, TOMM40 (Humphries et al. 2005) and VDAC1 (Kozjak-Pavlovic et al. 2007, homologous to yeast Porin1) have been shown to be substrates. Many other mitochondrial proteins are anticipated to be substrates of the SAMM50 complex.

Literature References
PubMed ID Title Journal Year
15644312 Dissection of the mitochondrial import and assembly pathway for human Tom40

Humphries, AD, Streimann, IC, Stojanovski, D, Johnston, AJ, Yano, M, Hoogenraad, NJ, Ryan, MT

J Biol Chem 2005
17510655 Conserved roles of Sam50 and metaxins in VDAC biogenesis

Kozjak-Pavlovic, V, Ross, K, Benlasfer, N, Kimmig, S, Karlas, A, Rudel, T

EMBO Rep 2007
19453276 Multiple pathways for mitochondrial protein traffic

Endo, T, Yamano, K

Biol Chem 2009
18174896 Multiple pathways for sorting mitochondrial precursor proteins

Bolender, N, Sickmann, A, Wagner, R, Meisinger, C, Pfanner, N

EMBO Rep 2008
Participants
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Catalyst Activity
Catalyst Activity
Title
membrane insertase activity of SAM complex [mitochondrial outer membrane]
Physical Entity
Activity
Inferred From
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