Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TOMM70 [mitochondrial outer membrane]
Stable Identifier
R-HSA-1252129
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
TOMM70A, Mitochondrial import receptor subunit TOM70, TOM70_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)
TOMM40 Complex [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome (Homo sapiens)
3a:NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] (Homo sapiens)
NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] (Homo sapiens)
NLRP3 oligomer:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
NLRP3:MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane] (Homo sapiens)
NLRP3 oligomer:MAVS:TRAF3 [mitochondrial outer membrane] (Homo sapiens)
NLRP3:MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
SARS-CoV-1 9b binds TOMM70 (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70:9b [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70:9b [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
SARS-CoV-2 9b binds TOMM70 (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70:9b [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
MAVS binds TOMM70 (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM70:9b [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
USP30:MOM proteins [mitochondrial outer membrane] (Homo sapiens)
MOM proteins [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space (Homo sapiens)
TOMM40 Complex [mitochondrial outer membrane] (Homo sapiens)
TOMM70 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94826 TOMM70
Gene Names
TOMM70, KIAA0719, TOM70, TOMM70A
Chain
initiator methionine:, chain:2-608
Reference Genes
BioGPS Gene:9868 TOMM70
COSMIC (genes):TOMM70 TOMM70
CTD Gene:9868 TOMM70
dbSNP Gene:9868 TOMM70
ENSEMBL:ENSG00000154174 TOMM70
HGNC:11985 TOMM70
KEGG:hsa:9868 TOMM70
Monarch:9868 TOMM70
NCBI Gene:9868 TOMM70
OMIM:606081 TOMM70
UCSC:O94826 TOMM70
Reference Transcript
RefSeq:NM_014820.4 TOMM70
Other Identifiers
11719015_a_at
11750848_a_at
11757770_s_at
16956773
201512_PM_s_at
201512_s_at
201519_PM_at
201519_at
2686372
2686373
2686374
2686375
2686377
2686378
2686380
2686381
2686382
2686383
2686384
2686385
2686386
2686387
2686389
2686390
2686391
2686392
2686394
2686397
2686398
2686399
32853_at
56773_at
8089128
9868
A_23_P144264
GE53441
GO:0002218
GO:0002230
GO:0002376
GO:0005215
GO:0005515
GO:0005739
GO:0005741
GO:0005742
GO:0006626
GO:0006886
GO:0007005
GO:0008320
GO:0016020
GO:0030150
GO:0030943
GO:0031966
GO:0032728
GO:0042981
GO:0043226
GO:0045039
GO:0045040
GO:0055085
GO:0060090
GO:0061024
GO:0061052
GO:0070062
GO:0097068
GO:0098586
GO:0140596
GO:1903955
HMNXSV003039265
ILMN_1746426
PH_hs_0032921
TC03001611.hg
g13177705_3p_a_at
g7662672_3p_at
Participates
as a candidate of
MOM proteins [mitochondrial outer membrane] (Homo sapiens)
as a component of
TOMM70:9b [mitochondrial outer membrane] (Homo sapiens)
TOMM70:9b [mitochondrial outer membrane] (Homo sapiens)
MAVS:TOMM70 [mitochondrial outer membrane] (Homo sapiens)
TOMM40 Complex [mitochondrial outer membrane] (Homo sapiens)
as an input of
SARS-CoV-1 9b binds TOMM70 (Homo sapiens)
SARS-CoV-2 9b binds TOMM70 (Homo sapiens)
MAVS binds TOMM70 (Homo sapiens)
Other forms of this molecule
PolyUb-TOMM70A [mitochondrial outer membrane]
Inferred To
Tom70 [mitochondrial outer membrane]
(Drosophila melanogaster)
Tomm70 [mitochondrial outer membrane]
(Mus musculus)
Tomm70 [mitochondrial outer membrane]
(Rattus norvegicus)
tomm70a [mitochondrial outer membrane]
(Danio rerio)
tom70 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
tomm-70 [mitochondrial outer membrane]
(Caenorhabditis elegans)
TOMM70 [mitochondrial outer membrane]
(Bos taurus)
TOMM70 [mitochondrial outer membrane]
(Canis familiaris)
TOMM70 [mitochondrial outer membrane]
(Gallus gallus)
TOMM70 [mitochondrial outer membrane]
(Sus scrofa)
tomm70 [mitochondrial outer membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_055635.3
ENSEMBL
ENST00000284320
,
ENSP00000284320
,
ENSG00000154174
OpenTargets
ENSG00000154174
GeneCards
TOMM70
HPA
ENSG00000154174-TOMM70
PRO
O94826
Pharos - Targets
O94826
GlyGen
O94826
PDB
7KDT
,
7DHG
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTD2 9b
3
p-S53-9b [cytosol]
(R-COV-9758478)
9b [cytosol]
(R-COV-9694649)
9b [mitochondrial outer membrane]
(R-COV-9709803)
0.976
28
UniProt:P59636 9b
2
9b [mitochondrial outer membrane]
(R-COV-9685182)
9b [cytosol]
(R-COV-9689378)
0.691
7
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text