PLCG1 phosphorylation by p-EGFR:p-ERBB2

Stable Identifier
R-HSA-1251922
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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PLCG1 phosphorylation by p-EGFR:p-ERBB2
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Phospholipase C gamma 1 (PLCG1) is phosphorylated by phosphorylated EGFR:ERBB2 heterodimer (Fazioli et al. 1991, Cohen et al. 1996).

Literature References
PubMed ID Title Journal Year
1672440 The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

Fazioli, F, Kim, UH, Rhee, SG, Molloy, CJ, Segatto, O, Di Fiore, PP

Mol Cell Biol 1991
8940074 The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

Cohen, BD, Kiener, PA, Green, JM, Foy, L, Fell, HP, Zhang, K

J Biol Chem 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
Physical Entity
EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Plcg1 phosphorylation by P-ERBB2:P-EGFR (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-25)
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