PLCG1 phosphorylation by p-EGFR:p-ERBB2

Stable Identifier
R-HSA-1251922
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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PLCG1 phosphorylation by p-EGFR:p-ERBB2
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Phospholipase C gamma 1 (PLCG1) is phosphorylated by phosphorylated EGFR:ERBB2 heterodimer (Fazioli et al. 1991, Cohen et al. 1996).

Literature References
PubMed ID Title Journal Year
8940074 The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

Fell, HP, Kiener, PA, Foy, L, Zhang, K, Green, JM, Cohen, BD

J Biol Chem 1996
1672440 The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

Di Fiore, PP, Rhee, SG, Kim, UH, Fazioli, F, Segatto, O, Molloy, CJ

Mol Cell Biol 1991
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]

Physical Entity
EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Plcg1 phosphorylation by P-ERBB2:P-EGFR (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-25)
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