Reactome | AQP1 tetramer transports CO2 from cytosol to extracellular region

AQP1 tetramer transports CO2 from cytosol to extracellular region

Stable Identifier

R-HSA-1247649

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region

ReviewStatus

5/5

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AQP1 tetramer transports CO2 from cytosol to extracellular region

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Aquaporin-1 (AQP1) passively transports carbon dioxide (CO2) across the plasma membrane according to the concentration gradient (Nakhoul et al. 1998, Blank & Ehmke et al. 2003, Endeward et al. 2006, Musa-Aziz et al. 2009). The pore in AQP1 that conducts CO2 may be distinct from the pore that conducts water.

Literature References

PubMed ID	Title	Journal	Year
19273840	Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG Musa-Aziz, R, Chen, LM, Pelletier, MF, Boron, WF	Proc Natl Acad Sci U S A	2009
12754312	Aquaporin-1 and HCO3(-)-Cl- transporter-mediated transport of CO2 across the human erythrocyte membrane Blank, ME, Ehmke, H	J Physiol	2003
17012249	Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane Endeward, V, Musa-Aziz, R, Cooper, GJ, Chen, LM, Pelletier, MF, Virkki, LV, Supuran, CT, King, LS, Boron, WF, Gros, G	FASEB J	2006
16563834	Red cell membrane CO2 permeability in normal human blood and in blood deficient in various blood groups, and effect of DIDS Endeward, V, Cartron, JP, Ripoche, P, Gros, G	Transfus Clin Biol	2006
9486145	Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes Nakhoul, NL, Davis, BA, Romero, MF, Boron, WF	Am J Physiol	1998