AQP1 tetramer transports CO2 from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region
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Aquaporin-1 (AQP1) passively transports carbon dioxide (CO2) across the plasma membrane according to the concentration gradient (Nakhoul et al. 1998, Blank & Ehmke et al. 2003, Endeward et al. 2006, Musa-Aziz et al. 2009). The pore in AQP1 that conducts CO2 may be distinct from the pore that conducts water.

Literature References
PubMed ID Title Journal Year
19273840 Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG

Pelletier, MF, Chen, LM, Boron, WF, Musa-Aziz, R

Proc Natl Acad Sci U S A 2009
12754312 Aquaporin-1 and HCO3(-)-Cl- transporter-mediated transport of CO2 across the human erythrocyte membrane

Blank, ME, Ehmke, H

J Physiol 2003
17012249 Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane

Virkki, LV, Pelletier, MF, Supuran, CT, Endeward, V, Gros, G, Chen, LM, Cooper, GJ, Boron, WF, King, LS, Musa-Aziz, R

FASEB J 2006
16563834 Red cell membrane CO2 permeability in normal human blood and in blood deficient in various blood groups, and effect of DIDS

Cartron, JP, Endeward, V, Gros, G, Ripoche, P

Transfus Clin Biol 2006
9486145 Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes

Romero, MF, Davis, BA, Nakhoul, NL, Boron, WF

Am J Physiol 1998
Event Information
Catalyst Activity

carbon dioxide transmembrane transporter activity of AQP1 tetramer [plasma membrane]

Orthologous Events
Cross References
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