AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol

Stable Identifier
R-HSA-1237042
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aquaporin-1 (AQP1) passively transports carbon dioxide (CO2) across the plasma membrane according to the concentration gradient (Nakhoul et al. 1998, Blank & Ehmke et al. 2003, Endeward et al. 2006, Musa-Aziz et al. 2009). The pore in AQP1 that conducts CO2 may be distinct from the pore that conducts water.

Literature References
PubMed ID Title Journal Year
12754312 Aquaporin-1 and HCO3(-)-Cl- transporter-mediated transport of CO2 across the human erythrocyte membrane

Blank, ME, Ehmke, H

J Physiol 2003
19273840 Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG

Musa-Aziz, R, Chen, LM, Pelletier, MF, Boron, WF

Proc Natl Acad Sci U S A 2009
17012249 Evidence that aquaporin 1 is a major pathway for CO2 transport across the human erythrocyte membrane

Endeward, V, Musa-Aziz, R, Cooper, GJ, Chen, LM, Pelletier, MF, Virkki, LV, Supuran, CT, King, LS, Boron, WF, Gros, G

FASEB J 2006
16563834 Red cell membrane CO2 permeability in normal human blood and in blood deficient in various blood groups, and effect of DIDS

Endeward, V, Cartron, JP, Ripoche, P, Gros, G

Transfus Clin Biol 2006
9486145 Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes

Nakhoul, NL, Davis, BA, Romero, MF, Boron, WF

Am J Physiol 1998
Participants
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Catalyst Activity
Catalyst Activity
Title
carbon dioxide transmembrane transporter activity of AQP1 tetramer [plasma membrane]
Physical Entity
Activity
Orthologous Events
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