Carbonic anhydrase IV (CA4) located on the extracellular face of the plasma membrane (Wistrand et al. 1999) dehydrates bicarbonate (HCO3--) to yield water and carbon dioxide (CO2) (Zhu & Sly 1990, Okayuma et al. 1992, Baird et al. 1997, Innocenti et al. 2004, reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.
Sly, WS, Fierke, CA, Okuyama, T, Baird TT, Jr, Waheed, A
Sly, WS, Zhu, XL
Innocenti, A, Wurl, M, Supuran, CT, Scozzafava, A, Antel, J, Firnges, MA
Sly, WS, Sato, S, Okuyama, T, Waheed, A, Zhu, XL
Carter, ND, Wistrand, PJ, Conroy, CW, Mahieu, I
Lindskog, S
carbonate dehydratase activity of CA4:Zn2+ [plasma membrane]
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