Reactome | CA4:Zn2+ dehydrates HCO3- to CO2

CA4:Zn2+ dehydrates HCO3- to CO2

Stable Identifier

R-HSA-1237059

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide, H+ + HCO3- -> H2O + CO2

ReviewStatus

5/5

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Carbonic anhydrase IV (CA4) located on the extracellular face of the plasma membrane (Wistrand et al. 1999) dehydrates bicarbonate (HCO3--) to yield water and carbon dioxide (CO2) (Zhu & Sly 1990, Okayuma et al. 1992, Baird et al. 1997, Innocenti et al. 2004, reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.

Literature References

PubMed ID	Title	Journal	Year
9054574	Catalysis and inhibition of human carbonic anhydrase IV Baird TT, Jr, Waheed, A, Okuyama, T, Sly, WS, Fierke, CA	Biochemistry	1997
2111324	Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney Zhu, XL, Sly, WS	J Biol Chem	1990
15501038	Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions Innocenti, A, Firnges, MA, Antel, J, Wurl, M, Scozzafava, A, Supuran, CT	Bioorg Med Chem Lett	2004
1311094	Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes Okuyama, T, Sato, S, Zhu, XL, Waheed, A, Sly, WS	Proc Natl Acad Sci U S A	1992
10090333	Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes Wistrand, PJ, Carter, ND, Conroy, CW, Mahieu, I	Acta Physiol Scand	1999
9336012	Structure and mechanism of carbonic anhydrase Lindskog, S	Pharmacol Ther	1997