CA4:Zn2+ dehydrates HCO3- to CO2

Stable Identifier
R-HSA-1237059
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide, H+ + HCO3- -> H2O + CO2
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Carbonic anhydrase IV (CA4) located on the extracellular face of the plasma membrane (Wistrand et al. 1999) dehydrates bicarbonate (HCO3--) to yield water and carbon dioxide (CO2) (Zhu & Sly 1990, Okayuma et al. 1992, Baird et al. 1997, Innocenti et al. 2004, reviewed in Lindskog 1997). Depending on the concentrations of reactants the reaction is reversible.

Literature References
PubMed ID Title Journal Year
2111324 Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney

Zhu, XL, Sly, WS

J Biol Chem 1990
9054574 Catalysis and inhibition of human carbonic anhydrase IV

Baird TT, Jr, Waheed, A, Okuyama, T, Sly, WS, Fierke, CA

Biochemistry 1997
15501038 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions

Innocenti, A, Firnges, MA, Antel, J, Wurl, M, Scozzafava, A, Supuran, CT

Bioorg Med Chem Lett 2004
1311094 Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes

Okuyama, T, Sato, S, Zhu, XL, Waheed, A, Sly, WS

Proc Natl Acad Sci U S A 1992
10090333 Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes

Wistrand, PJ, Carter, ND, Conroy, CW, Mahieu, I

Acta Physiol Scand 1999
9336012 Structure and mechanism of carbonic anhydrase

Lindskog, S

Pharmacol Ther 1997
Participants
Participates
Event Information
Catalyst Activity

carbonate dehydratase activity of CA4:Zn2+ [plasma membrane]

Orthologous Events
Authored
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