AhpD reactivates AhpC

Stable Identifier
R-HSA-1222655
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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AhpD reactivates AhpC
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from lpdC, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).

Literature References
PubMed ID Title Journal Year
21238944 Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes

Venugopal, A, Bryk, R, Shi, S, Rhee, K, Rath, P, Schnappinger, D, Ehrt, S, Nathan, C

Cell Host Microbe 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
disulfide oxidoreductase activity of AhpD trimer [cytosol]
Physical Entity
AhpD trimer [cytosol]
Activity
disulfide oxidoreductase activity (0015036)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Target Pathogen
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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