Reactome | Activated IKK phosphorylates I-kappaB

Activated IKK phosphorylates I-kappaB

Stable Identifier

R-HSA-1168638

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated IKK complex phosphorylates the I-kappaB component of the cytoplasmic NF-kappaB complex (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999). B cells contain I-kappaB-alpha, I-kappaB-beta, and I-kappaB-epsilon (Whiteside et al. 1997, Li and Nabel 1997).

Literature References

PubMed ID	Title	Journal	Year
9315679	A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription Li, Z, Nabel, GJ	Mol Cell Biol	1997
9135156	I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity Whiteside, ST, Epinat, JC, Rice, NR, Israel, A	EMBO J	1997
9721103	Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate Zandi, E, Chen, Y, Karin, M	Science	1998
9914500	All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex Heilker, R, Freuler, F, Pulfer, R, di Padova, F, Eder, J	Eur J Biochem	1999
10593898	Peptides corresponding to the N and C termini of IkappaB-alpha, -beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 and IKK-2 Burke, JR, Wood, MK, Ryseck, RP, Walther, S, Meyers, CA	J Biol Chem	1999