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p-CARMA1:MALT1:p-BCL10:TAK1 [plasma membrane]
Stable Identifier
R-HSA-1168619
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
p-CARMA1:MALT1:p-BCL10:TAK1 [plasma membrane] (Homo sapiens)
General
TAK1 and the IKK complex are observed to migrate to lipid rafts containing phosphorylated CARMA1, BCL10, and MALT1. By analogy with NF-kappaB signaling pathways in other cells, the CARMA1:BCL10MALT1:TAK1:IKK complex in B cells may also contain TAB1, TAB2 and/or TAB3, TRAF6.
Participants
components
MAP3K7 [cytosol]
(Homo sapiens)
p-CARMA1:MALT1:p-BCL10 [plasma membrane]
(Homo sapiens)
Participates
as an output of
TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
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