TAK1 associated with the CBM complex phosphorylates IKKbeta

Stable Identifier
Reaction [transition]
Homo sapiens
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TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.
Literature References
PubMed ID Title Journal Year
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Deng, L, Inoue, J, Akkaraju, GR, Hong, M, Wang, C, Chen, ZJ

Nature 2001
16301747 PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1

Shinohara, H, Sakurai, H, Sanjo, H, Aiba, Y, Hamadate, M, Yasuda, T, Watarai, H, Kurosaki, T

J Exp Med 2005
20449947 Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes

Zeng, XF, Wu, XL, Lipsky, PE, Zhang, W, Crammer, AC, He, LS, Zhang, X

Chin Med Sci J 2010
19909372 Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling

Shinohara, H, Kurosaki, T

Immunol Rev 2009
14695475 Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

Dixit, VM, O'Rourke, K, Eby, M, Ultsch, M, Xiao, W, Wertz, I, Zhou, H, Seshagiri, S

Nature 2004
Catalyst Activity

protein serine/threonine kinase activity of p-CARMA1:MALT1:p-BCL10:TAK1:IKK [plasma membrane]

Inferred From
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