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PPBP(35-128) [extracellular region]
Stable Identifier
R-HSA-114573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PPBP, Beta-thromboglobulin
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of tertiary granule lumen proteins (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
PPBP(35-128) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02775 PPBP
Gene Names
PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1
Chain
signal peptide:1-34, chain:35-128, chain:44-128, chain:44-126, chain:44-124, chain:48-128, chain:55-128, chain:56-128, chain:59-128, chain:59-126, chain:59-124, chain:59-121
Reference Genes
BioGPS Gene:5473 PPBP
COSMIC (genes):PPBP PPBP
CTD Gene:5473 PPBP
dbSNP Gene:5473 PPBP
ENSEMBL:ENSG00000163736.4 PPBP
HGNC:9240 PPBP
KEGG Gene (Homo sapiens):5473 PPBP
Monarch:5473 PPBP
NCBI Gene:5473 PPBP
OMIM:121010 PPBP
UCSC:P02775 PPBP
Reference Transcript
RefSeq:NM_002704.3 PPBP
Other Identifiers
11743087_at
16976821
214146_PM_s_at
214146_s_at
2773357
2773359
2773360
2773361
2773363
2773364
2773365
2773366
39208_i_at
39209_r_at
5473
8100971
A_23_P121596
GE57965
GO:0002376
GO:0005125
GO:0005215
GO:0005355
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006952
GO:0006954
GO:0006955
GO:0008009
GO:0008083
GO:0009605
GO:0023052
GO:0030593
GO:0031093
GO:0031410
GO:0042742
GO:0043226
GO:0045236
GO:0048018
GO:0048870
GO:0051781
GO:0055085
GO:0061844
GO:0070098
GO:0071222
GO:0098542
GO:0098772
GO:1904659
GO:1904724
HMNXSV003055572
Hs.2164.1.A1_3p_a_at
ILMN_1767281
M54995_at
PH_hs_0000287
TC04001282.hg
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
Other forms of this molecule
PPBP(55-128) [extracellular region]
PPBP(55-128) [platelet alpha granule lumen]
PPBP(35-128) [platelet alpha granule lumen]
PPBP(35-128) [tertiary granule lumen]
Inferred To
cxcl-c5c [extracellular region]
(Danio rerio)
cxcl8 [extracellular region]
(Xenopus tropicalis)
PPBP(35-128) [extracellular region]
(Canis familiaris)
PPBP(35-128) [extracellular region]
(Danio rerio)
PPBP(35-128) [extracellular region]
(Gallus gallus)
cxcl2 [extracellular region]
(Xenopus tropicalis)
il8l1 [extracellular region]
(Danio rerio)
CXCL8 [extracellular region]
(Danio rerio)
CXCL8 [extracellular region]
(Xenopus tropicalis)
Ppbp [extracellular region]
(Mus musculus)
Ppbp [extracellular region]
(Rattus norvegicus)
cxcl8b.2 [extracellular region]
(Xenopus tropicalis)
Homologues of PPBP(35-128) [extracellular region]
(Danio rerio)
Homologues of PPBP(35-128) [extracellular region]
(Xenopus tropicalis)
PPBP [extracellular region]
(Sus scrofa)
LOC100498389 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002695.1
OpenTargets
ENSG00000163736
GeneCards
P02775
HPA
ENSG00000163736-PPBP
Ensembl
ENST00000296028
,
ENSP00000296028
,
ENSG00000163736
PRO
P02775
Pharos - Targets
P02775
PDB
1F9P
,
1TVX
,
1NAP
HMDB Protein
HMDBP02768
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
UniProt:P06307 CCK
1
CCK [extracellular region]
(R-HSA-388539)
0.556
3
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