Reactome | PPBP(35-128) [extracellular region]

PPBP(35-128) [extracellular region]

Stable Identifier

R-HSA-114573

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

PPBP, Beta-thromboglobulin

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        PPBP(35-128) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02775 PPBP

Gene Names

PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1

Chain

signal peptide:1-34, chain:35-128, chain:44-128, chain:44-126, chain:44-124, chain:48-128, chain:55-128, chain:56-128, chain:59-128, chain:59-126, chain:59-124, chain:59-121

Reference Genes

BioGPS Gene:5473 PPBP

COSMIC (genes):PPBP PPBP

CTD Gene:5473 PPBP

dbSNP Gene:5473 PPBP

ENSEMBL:ENSG00000163736 PPBP

HGNC:9240 PPBP

KEGG:hsa:5473 PPBP

Monarch:5473 PPBP

NCBI Gene:5473 PPBP

OMIM:121010 PPBP

UCSC:P02775 PPBP

Reference Transcript

RefSeq:NM_002704.3 PPBP

Other Identifiers

11743087_at

16976821

214146_PM_s_at

214146_s_at

2773357

2773359

2773360

2773361

2773363

2773364

2773365

2773366

39208_i_at

39209_r_at

5473

8100971

A_23_P121596

GE57965

GO:0002376

GO:0005125

GO:0005215

GO:0005355

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0008009

GO:0008083

GO:0030593

GO:0031093

GO:0042742

GO:0045236

GO:0048018

GO:0048870

GO:0051781

GO:0055085

GO:0061844

GO:0070098

GO:0071222

GO:0098542

GO:0098772

GO:1904659

GO:1904724

HMNXSV003055572

Hs.2164.1.A1_3p_a_at

ILMN_1767281

M54995_at

PH_hs_0000287

TC04001282.hg

Participates

as a member of

Other forms of this molecule

PPBP(35-128) [tertiary granule lumen]

PPBP(55-128) [extracellular region]

PPBP(55-128) [platelet alpha granule lumen]

PPBP(35-128) [platelet alpha granule lumen]

Inferred To

PPBP(35-128) [extracellular region] (Rattus norvegicus)

cxcl8b.1 [extracellular region] (Danio rerio)

Ppbp [extracellular region] (Mus musculus)

Homologues of PPBP(35-128) [extracellular region] (Danio rerio)

cxcl8b.3 [extracellular region] (Danio rerio)

PPBP [extracellular region] (Canis familiaris)

PPBP [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002695.1

ENSEMBL

ENSG00000163736, ENST00000296028, ENSP00000296028

OpenTargets

ENSG00000163736

GeneCards

PPBP

HPA

ENSG00000163736-PPBP

PRO

P02775

Pharos - Targets

P02775

HMDB Protein

HMDBP02768

PDB

1NAP, 1F9P, 1TVX

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3