Detection of damage during initiation of DNA synthesis in S-phase

Stable Identifier
R-HSA-113504
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Detection of damage during initiation of DNA synthesis in S-phase
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present. At the end of this reaction, 1 molecule of 'DNA polymerase alpha:primase', and 1 molecule of 'RNA primer-DNA primer:origin duplex with DNA damage' are present.
This reaction takes place in the 'nucleus' (Gambus et al. 2009, Remus et al. 2009, Chattopadhyay et al.2007, Fien et al. 2004).
Literature References
PubMed ID Title Journal Year
19896182 Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

Remus, D, Beuron, F, Tolun, G, Griffith, JD, Morris, EP, Diffley, JF

Cell 2009
17699597 Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication

Chattopadhyay, S, Bielinsky, AK

Mol. Biol. Cell 2007
14766746 Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p

Fien, K, Cho, YS, Lee, JK, Raychaudhuri, S, Tappin, I, Hurwitz, J

J Biol Chem 2004
19661920 A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A, van Deursen, F, Polychronopoulos, D, Foltman, M, Jones, RC, Edmondson, RD, Calzada, A, Labib, K

EMBO J. 2009
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Orthologous Events
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Detection of damage during initiation of DNA synthesis in S-phase (Gallus gallus)
Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)
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Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)
Detection of damage during initiation of DNA synthesis in S-phase (Saccharomyces cerevisiae)
Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)
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Created
Bosco, G  (2004-06-16)
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