Detection of damage during initiation of DNA synthesis in S-phase

Stable Identifier
R-HSA-113504
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present. At the end of this reaction, 1 molecule of 'DNA polymerase alpha:primase', and 1 molecule of 'RNA primer-DNA primer:origin duplex with DNA damage' are present.
This reaction takes place in the 'nucleus' (Gambus et al. 2009, Remus et al. 2009, Chattopadhyay et al.2007, Fien et al. 2004).

Literature References
PubMed ID Title Journal Year
17699597 Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication

Chattopadhyay, S, Bielinsky, AK

Mol. Biol. Cell 2007
19896182 Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

Remus, D, Beuron, F, Tolun, G, Griffith, JD, Morris, EP, Diffley, JF

Cell 2009
14766746 Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p

Fien, K, Cho, YS, Lee, JK, Raychaudhuri, S, Tappin, I, Hurwitz, J

J Biol Chem 2004
19661920 A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A, van Deursen, F, Polychronopoulos, D, Foltman, M, Jones, RC, Edmondson, RD, Calzada, A, Labib, K

EMBO J. 2009
Participants
Participant Of
Orthologous Events
Created