Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Stable Identifier
Reaction [transition]
Homo sapiens
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FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE).
Literature References
PubMed ID Title Journal Year
9765293 FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO

Archambault, J, Pan, G, Marshall, N, Cartier, M, Dahmus, ME, Dahmus, GK, Greenblatt, J, Zhang, S

J. Biol. Chem. 1998
12370301 FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation.

Mandal, SS, Reinberg, D, Cabane, K, Cho, H, Kim, S

Mol Cell Biol 2002
Catalyst Activity

phosphoprotein phosphatase activity of CTDP1 [nucleoplasm]

Orthologous Events
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