Reactome | Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Hypophosphorylation of RNA Pol II CTD by FCP1P protein

Stable Identifier

R-HSA-112383

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Hypophosphorylation of RNA Pol II CTD by FCP1P protein

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FCP1 dephosphorylates RNAP II in ternary elongation complexes as well as in solution and is thought to function in the recycling of RNAP II during the transcription cycle. Biochemical experiments suggest that human FCP1 targets CTDs that are phosphorylated at serine 2 (CTD-serine 2) and/or CTD-serine 5. It is also observed to stimulate elongation independent of its catalytic activity. Dephosphorylation of Ser2 - phosphorylated Pol II results in hypophosphorylated form that disengages capping enzymes (CE).

Literature References

PubMed ID	Title	Journal	Year
9765293	FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO Archambault, J, Pan, G, Dahmus, GK, Cartier, M, Marshall, N, Zhang, S, Dahmus, ME, Greenblatt, J	J. Biol. Chem.	1998
12370301	FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mandal, SS, Cho, H, Kim, S, Cabane, K, Reinberg, D	Mol Cell Biol	2002