Phosphorylated STAT1, STAT3 form dimers

Stable Identifier
R-HSA-1112538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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STATs can form dimers in the unphosphorylated state but only phosphorylated dimers are in the correct conformation to to bind consensus DNA sequences of target genes in the nucleus (Riech & Liu 2006).

Literature References
PubMed ID Title Journal Year
8140422 Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Zhong, Z, Wen, Z, Darnell JE, Jr

Science 1994
9630226 Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

Chen, X, Vinkemeier, U, Zhao, Y, Jeruzalmi, D, Darnell JE, Jr, Kuriyan, J

Cell 1998
Participants
Participant Of
Orthologous Events
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