Phosphorylated STAT1, STAT3 form dimers

Stable Identifier
R-HSA-1112538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated STAT1, STAT3 form dimers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

STATs can form dimers in the unphosphorylated state but only phosphorylated dimers are in the correct conformation to to bind consensus DNA sequences of target genes in the nucleus (Riech & Liu 2006).

Literature References
PubMed ID Title Journal Year
8140422 Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Zhong, Z, Wen, Z, Darnell JE, Jr

Science 1994
9630226 Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

Chen, X, Vinkemeier, U, Zhao, Y, Jeruzalmi, D, Darnell JE, Jr, Kuriyan, J

Cell 1998
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Phosphorylated STAT1, STAT3 form dimers (Bos taurus)
Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)
Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)
Phosphorylated STAT1, STAT3 form dimers (Danio rerio)
Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)
Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)
Phosphorylated STAT1, STAT3 form dimers (Gallus gallus)
Phosphorylated STAT1, STAT3 form dimers (Mus musculus)
Phosphorylated STAT1, STAT3 form dimers (Rattus norvegicus)
Phosphorylated STAT1, STAT3 form dimers (Sus scrofa)
Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-12-03)