Phosphorylated STAT1, STAT3 form dimers

Stable Identifier
R-HSA-1112538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylated STAT1, STAT3 form dimers
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
STATs can form dimers in the unphosphorylated state but only phosphorylated dimers are in the correct conformation to to bind consensus DNA sequences of target genes in the nucleus (Riech & Liu 2006).
Literature References
PubMed ID Title Journal Year
9630226 Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

Vinkemeier, U, Chen, X, Darnell JE, Jr, Jeruzalmi, D, Zhao, Y, Kuriyan, J

Cell 1998
8140422 Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Darnell JE, Jr, Zhong, Z, Wen, Z

Science 1994
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Orthologous Events
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Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)
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Phosphorylated STAT1, STAT3 form dimers (Mus musculus)
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Phosphorylated STAT1, STAT3 form dimers (Xenopus tropicalis)
Authored
Ray, KP  (2010-12-13)
Reviewed
Rose-John, S  (2011-02-11)
Created
Jupe, S  (2010-12-03)
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